Protein quality control in Health and Disease

Protein quality control in Health and Disease 28 – 29 May

The viability of all organisms depends on maintaining a healthy proteome. Endogenous and exogenous challenges, including developmental programs, environmental insults, and disease conditions, jeopardize protein homeostasis. The heat shock response, integrated stress response, and unfolded protein response are examples of complex molecular systems that detect and respond to proteotoxic stress. In addition, ribosome quality control has emerged as a key regulator of proteome integrity. The importance of proteostasis is underscored by the many human diseases associated with or caused by malfunctions in translation quality control and stress responses. These include many neurodegenerative disorders and non-neurological conditions, such as diabetes, cardiac, lung, and liver diseases, infections, and cancer. The diverse pathologies underscore the importance of promoting a concerted multidisciplinary effort to understand the players and rules of proteostasis. 

The conference brings together leading researchers in various aspects of proteostasis, offering a unique platform for exchanging ideas and presenting cutting-edge findings. Key topics will include protein synthesis, folding, and degradation; the effectors and regulators of the quality control machinery and stress responses; and the regulation of these processes in aging and disease. 

For programme, please click here:

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Contact: Veronika Eriksson
Email: veronika.eriksson@kva.se