A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy to tumor dynamics, enabling adaptable responses of tumor cells during initiation, progression, and treatment evasion. In this meeting, we explore the pivotal role of brain tumor plasticity in shaping a heterogeneous tumor ecosystem, where diverse phenotypic states coexist, interact with each other, and with the evolving tumor microenvironment. The discussion encompasses how phenotypic heterogeneity and plasticity contribute to the development of therapeutic resistance, and the therapeutic potential of targeting molecular regulators that influence brain tumor heterogeneity and plasticity
The symposium is funded by Ragnar Söderbergs stiftelse.
This is free of charge event with lunch included in the official program.
PROGRAMME
8.30-9.00
Registration and coffee
9.00-9.15
Welcome address
Alexander Pietras, Margareta Wilhelm, Silvia Remeseiro, Fredrik Swartling
Session 1: Cancer neuroscience
Chairs: Alexander Pietras and Fredrik Swartling
9.15-10.00
Frank Winkler, DKFZ, University Hospital Heidelberg, Heidelberg, Germany
10.00 Coffee break
10.30-11.15
Marie Carlén, Karolinska Institutet, Stockholm, Sweden
11.15 – 12.00
Single-Cell and Spatial omics in Development and Disease
Gonçalo Castelo-Branco, Karolinska Institutet, Stockholm, Sweden
12.00-13.00 Lunch
Session 2: The evolving brain tumor microenvironment
Chair: Margareta Wilhelm
13.00-13.45
Leila Akkari, Netherlands Cancer Institute, Amsterdam, the Netherlands
13.45-14.30
Anna Dimberg, Uppsala University, Uppsala, Sweden
14.30-15.15
Mattias Belting, Lund University, Lund, Sweden
15.15-15.35 Coffee break
Session 3: Data-driven insights into brain tumor progression and plasticity
Chair: Silvia Remeseiro
15.35-16.20
Claudia Kleinman, McGill University, Montreal, Canada
16.20-17.05
Sven Nelander, Uppsala University, Uppsala, Sweden
17.05-17.15 Closing remarks
Alexander Pietras, Margareta Wilhelm, Silvia Remeseiro, Fredrik Swartling
17.15 End of symposium
17.15 – 18.30
Mingel reception for all participants
This event will be broadcasted live and recorded.
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Contact: Veronika Eriksson
Email: program@kva.se